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The song, about life on tour, came about when the executive producer of the film Honeysuckle Rose approached Nelson about writing the song for the film's soundtrack. "On the Road Again" became Nelson's 9th Country & Western No. 1 hit overall (6th as a solo recording act) in November 1980, and became one of Nelson's most recognizable tunes. It was his biggest pop hit to that time and won him a Grammy Award for Best Country Song a year later.